应实验室国际清洁可再生能源研究中心邀请，魁北克大学国家科学研究院Fiorenzo Vetrone副教授将于2015年4月27日来我实验室交流访问，并做学术报告，请实验室师生积极参加。
讲座名称：Lanthanide-Doped Nanoparticles: Excitation in the Near-Infrared for Applications in Biology and Nanomedicine
讲座时间：4月27日（星期一）上午9:30-10:30
讲座地点：北二楼11层会议室
讲座人：Fiorenzo Vetrone副教授，魁北克大学国家科学研究院
讲座内容：
The ability to stimulate luminescent nanoparticles with near-infrared (NIR) light has made possible their use in a plethora of biological and medical applications. In fact, the biggest impact of such materials would be in the field of disease diagnostics and therapeutics, now commonly referred to as theranostics. The use of NIR light for excitation mitigates some of the drawbacks associated with high-energy light (UV or blue) excitation, for example, little to no background autofluorescence from the specimen under investigation as well as no incurred photodamage. Moreover, one of the biggest limitations is of course, that of penetration. As such, NIR light can penetrate tissues much better than UV or visible light especially when these wavelengths lie within the so-called biological windows. Thus, significant strides have been made in the synthesis of nanomaterials whose excitation as well as emission bands fall within one of these three optically transparent biological windows. In particular, hybrid core/shell nanostructures (Fig. 1) have attracted considerable attention for their ability to deliver several modalities in a single, optical nanoplatform
[1-3].
Here, we present the synthesis and surface functionalization of various NIR excited (and emitting) core/shell nanostructures and demonstrate their potential use in cell-labeling, bioimaging, and nanothermometry. Furthermore, we will show how such nanoparticles can be used as building blocks towards developing multifunctional nanoplatforms for the simultaneous diagnostics and therapeutics of diseases such as cancer.
Fig.1. Schematic of a hybrid core/shell nanostructure consisting of a gold nanorod core with a porous layer of upconverting NaYF4:Er3+, Yb3+that can have applications in cancer therapy. The gold nanorod core allows for optical
heating (nanoheater), while the outer layer with its temperature sensitive upconverted emission (the nanothermometer) can simultaneously monitor the temperature. Also an anti-cancer drug (doxorubicin) can be loaded in the porous outer shell allowing for a multi-pronged attack on cancer in the form of photothermal treatments and local chemotherapeutic drug release.
1. Y. Huang, F. Rosei and F. Vetrone,Nanoscale,7, 5178-5185 (2015)
2. E. Hemmer, M. Quintanilla, F. Légaré, F. Vetrone,Chem. Mater.,27, 235-244 (2015)
3. M. Quintanilla, F. Ren, D. Ma, F. Vetrone,ACS Photonics,1, 662-669 (2014)
讲座人简介：
Dr. Vetrone was appointed Assistant Professor of Nanobiotechnology at INRS-EMT in October 2010 to develop an ambitious and vigorous research programme at the vanguard of nanomaterials research and their implementation in the life sciences, nanomedicine, and environmental applications. The overarching theme of his research group is to develop a multi-functional nanoplatform, excited by nearinfrared light, to simultaneously trigger other light activated modalities. Dr. Vetrone is a pioneer in the field of lanthanidedoped upconverting nanoparticles, publishing the first paper in the field in the year 2000.Today, the field is steadfastly maturing with several thousand papers published on the topic. He has published over 65 papers in prestigious, high impact, peer-reviewed publications such asJournal of the American Chemical Society,Nano Letters,ACS Nano,Chemistry of Materials,Advanced Materials,Advanced Functional Materials,Nanoscale,Small, etc. His impact in the field is evident from the number of citations his work has garnered (over 5600), h-index (38), and the over 75 invited lectures at prestigious conferences, universities and summer schools. Moreover, he has won a number of prestigious awards from NSERC, IUPAC, the Royal Society (UK) etc. and has recently been elected as a member of the Global Young Academy. His research team consists of 16 trainees (4 PDF, 10 Ph.D., 2 M.Sc.) with diverse expertise in chemistry, physics, materials science, cell biology, pharmaceutical science, etc. His lab is fully equipped to synthesize all manner of nanoparticles and he has access to a suite of characterization equipment either in his lab or at INRS-EMT. The flagship of his laboratory, funded by
CFI, is the recently commissioned multiphoton microscope/hyperspectral imager, which is capable of acquiring fluorescent images coupled with the corresponding fluorescence spectrum with high resolution in almost real time. This instrument, unique in the country has detection limits spanning 350 -1700 nm.
